Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.
نویسندگان
چکیده
4Crawford, L. V., R. Dulbecco, M. Fried, L. Montagnier, and M. G. P. Stoker, these PNoCEEDINGS, 52, 148 (1964). Bourgaux, P., D. Bourgaux-Ramoisy, and M. G. P. Stoker, Virology, 25, 364 (1965). 6Black, P. H., and W. P. Rowe, these PROCEEDINGS, 50, 606 (1963). 7Diderholm, H., B. Stenkvist, J. Ponten, and T. Wesslen, Exptl. Cell Res., 37, 452 (1965). 8 Black, P. H., and W. P. Rowe, J. Nati. Cancer Inst., 32, 253 (1964). 9 Hopps, H. E., B. C. Bernheim, A. Nisalak, J. H. Tjio, and J. E. Smadel, J. Immunol., 91, 416 (1963). 10Black, P. H., E. M. Crawford, and L. V. Crawford, Virology, 24, 381 (1964). 11 Weil, R., Virology, 14 (1961). 12 Black, P. H., and W. P. Rowe, Virology, in press. 13 A clone of fibroblasts (C13), derived from the BHK-21 line,' was obtained from Professor M. Stoker, Giasgow, Scotland, and was used at the 80th-lOOth generations since cloning. 14 Pope, J. H., and W. P. Rowe, J. Exptl. Med., 120, 121 (1964). 16 Black, P. H., W. P. Rowe, H. C. Turner, and R. J. Huebner, these PROCEEDINGS, 50, 1148 (1963). 16 Defendi, V., J. Lehman, and P. Kraemer, Virology, 19, 592 (1963). 17 Black, P. H., and W. P. Rowe, Proc. Soc. Exptl. Biol. Med., 114, 721 (1963). 18 Gotlieb-Stematsky, T., and R. Shilo, Virology, 22, 314 (1964). 19 Dulbecco, R., personal communication. 20 Le Bouvier, G., personal communication. 21 Crawford, L. V., and P. H. Black, Virology, 24, 388 (1964). 22 Mayor, H. D., R. M. Jamison, and L. E. Jordan, Virology, 19, 359 (1963). 23Stoker, M., and P. Abel, in Cold Spring Harbor Symposia on Quantitative Biology, vol. 17, (1962), p. 375. 24 Black, P. H., unpublished data. 25 Vinograd, J., R. Bruner, R. Kent, and J. Weigle, these PROCEEDINGS, 49, 902 (1963).
منابع مشابه
Active-site-serine D-alanyl-D-alanine-cleaving-peptidase-catalysed acyl-transfer reactions
Under certain conditions, the values of the parameters that govern the interactions between the active-siteserine D-alanyl-D-alanine-cleaving peptidases and both carbonyl-donor substrates and ,J-lactam suicide substrates can be determined on the basis of the amounts of (serine ester-linked) acyl-protein formed during the reactions. Expressing the 'affinity' of a ,J-lactam compound for a DD-pept...
متن کاملActive-site-serine D-alanyl-D-alanine-cleaving-peptidase-catalysed acyl-transfer reactions. Procedures for studying the penicillin-binding proteins of bacterial plasma membranes.
Under certain conditions, the values of the parameters that govern the interactions between the active-site-serine D-alanyl-D-alanine-cleaving peptidases and both carbonyl-donor substrates and beta-lactam suicide substrates can be determined on the basis of the amounts of (serine ester-linked) acyl-protein formed during the reactions. Expressing the 'affinity' of a beta-lactam compound for a DD...
متن کاملRole of the D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid.
D-Alanyl-lipoteichoic acid (D-alanyl-LTA) is a widespread macroamphiphile which plays a vital role in the growth and development of gram-positive organisms. The biosynthesis of this polymer requires the enzymic activation of D-alanine for its transfer to the membrane-associated LTA (mLTA). A small, heat-stable, and acidic protein that is required for this transfer was purified to greater than 9...
متن کاملModifications of the acyl-D-alanyl-D-alanine terminus affecting complex-formation with vancomycin.
Vancomycin forms complexes with peptides terminating in d-alanyl-d-alanine that are analogous to the biosynthetic precursors of bacterial mucopeptides. The specificity of complex-formation has been studied by means of many synthetic peptides, prepared by both solid-phase and conventional methods. The following conclusions can be drawn: (a) three amide linkages are required to form a stable comp...
متن کاملDocking studies in target proteins involved in antibacterial action mechanisms: extending the knowledge on standard antibiotics to antimicrobial mushroom compounds.
In the present work, the knowledge on target proteins of standard antibiotics was extended to antimicrobial mushroom compounds. Docking studies were performed for 34 compounds in order to evaluate their affinity to bacterial proteins that are known targets for some antibiotics with different mechanism of action: inhibitors of cell wall synthesis, inhibitors of protein synthesis, inhibitors of n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 54 4 شماره
صفحات -
تاریخ انتشار 1965